Haense et al. have tested the performance of the PALZ tool with data from two different databases. The study confirms the high accuracy of FDG PET with PALZ for the discrimination between Alzheimer's Dementia patients and normal controls. Furthermore it demonstrates that PALZ can be equally applied to studies with eyes open or closed during the uptake phase. Only 7 out of 464 images had to be excluded from the analysis due to a failure of the normalization procedure.